ABC Proteins. From Bacteria to Man by I Barry Holland,Susan P. C. Cole,Karl Kuchler, et

By I Barry Holland,Susan P. C. Cole,Karl Kuchler, et al.Elsevier|Elsevier Science||Academic PressAdult NonfictionScienceLanguage(s): EnglishOn sale date: 13.10.2011Street date: 07.01.2003

ABC Proteins is an in-depth, up to date research of all that's identified concerning the topic to this point. It discusses and compares evolution, biology and mechanism of motion of all identified ABC proteins, together with the 1st structural reports in addition to medical implications. will probably be helpful to somebody attempting to remain abreast of the newest findings. This ebook is bound to turn into a vintage and should on a regular basis be updated.

Key Features

  • Phylogeny and Evoloution of ABC Transporters
  • Fundamental facets of the Mechanism of motion of ABC Transporters
  • Prokaryote ABC Transporters
  • Non-Mammalian Transporters
  • Multidrug Transporters
  • ABC Transporters, Physiological Roles and Human Disease
  • Full colour all through
  • Show description

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    Extra info for ABC Proteins. From Bacteria to Man

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    C. Cole Karl Kuchler Christopher F. Higgins Table of Contents Cover Title page Copyright CONTRIBUTORS THE EDITORS ABC TRANSPORTERS: AN INTRODUCTION AND OVERVIEW PART I: PHYLOGENY AND EVOLUTION OF ABC TRANSPORTERS Chapter 1: PHYLOGENETIC AND FUNCTIONAL CLASSIFICATION OF ABC (ATP-BINDING CASSETTE) SYSTEMS INTRODUCTION INVENTORY AND CLASSIFICATION OF ABC SYSTEMS FAMILIES OF ABC SYSTEMS IN LIVING ORGANISMS LESSONS FROM GENOME COMPARISONS CONCLUSIONS AND PERSPECTIVES Chapter 2: MEMBRANE TOPOLOGY OF THE HUMAN ABC TRANSPORTER PROTEINS INTRODUCTION METHODOLOGY MEMBRANE TOPOLOGY OF THE ABC TRANSPORTERS CONCLUSIONS Chapter 3: HUMAN AND DROSOPHILA ABC PROTEINS INTRODUCTION PHYLOGENETIC ANALYSIS OF HUMAN ABC GENES DROSOPHILA ABC GENES HUMAN ABC GENE SUBFAMILIES CONCLUSIONS AND PERSPECTIVES PART II: FUNDAMENTAL ASPECTS OF THE MECHANISM OF ACTION OF ABC TRANSPORTERS Chapter 4: STRUCTURE OF ABC TRANSPORTERS INTRODUCTION STRUCTURES OF NBDS STRUCTURES OF INTACT ABC TRANSPORTERS CONCLUSIONS ACKNOWLEDGMENTS Chapter 5: SUBSTRATE-BINDING SITES IN ABC TRANSPORTERS GENERAL INTRODUCTION PROPERTIES OF SUBSTRATES RECOGNIZED BY ABC TRANSPORTERS LOCATION(S) AND NUMBER OF SUBSTRATE-BINDING SITES IN ABC TRANSPORTERS STRUCTURAL AND FUNCTIONAL PROPERTIES OF SUBSTRATE-BINDING SITES COUPLING BETWEEN SUBSTRATE-BINDING SITES AND NUCLEOTIDE-BINDING DOMAINS THE TRANSPORT CYCLE OF ABC TRANSPORTERS CONCLUDING REMARKS ACKNOWLEDGMENTS Chapter 6: PROBING OF CONFORMATIONAL CHANGES, CATALYTIC CYCLE AND ABC TRANSPORTER FUNCTION INTRODUCTION THE CATALYTIC CYCLE OF PGP AND OTHER ABC TRANSPORTERS – AN OVERVIEW VACUUM CLEANER MODEL FOR ABC MULTIDRUG TRANSPORTERS PROBING CONFORMATIONAL CHANGES OF PGP DURING THE CATALYTIC CYCLE CONFORMATIONAL CHANGES IN OTHER ABC TRANSPORTERS DOMAIN INTERACTIONS IN ABC TRANSPORTERS Chapter 7: X-RAY STRUCTURE OF AN INTACT ABC TRANSPORTER, MSBA INTRODUCTION: THE MULTIDRUG RESISTANCE (MDR) ABC TRANSPORTERS STRUCTURAL STUDIES OF MDR-ABC TRANSPORTERS PROTEIN EXPRESSION PROTEIN PURIFICATION PROTEIN CRYSTALLIZATION CRYSTALLOGRAPHIC ANALYSIS STRUCTURE DESCRIPTION POSSIBLE FLIPPING MECHANISM ACKNOWLEDGMENTS PART III: PROKARYOTE ABC TRANSPORTERS Chapter 8: INTRODUCTION TO BACTERIAL ABC PROTEINS NATURE AND COMPOSITION OF THE ABC TRANSPORTER AN ABUNDANCE OF DIFFERENT TYPES OF ABC PROTEINS IN PROKARYOTES AN ADDITIONAL CLASS OF BACTERIAL ABCs INVOLVED IN DNA RECOMBINATION AND REPAIR EXPORTERS CLASS 2, ORPHAN ABCS IMPORTERS MEMBRANE DOMAINS OF THE BACTERIAL TRANSPORTERS ARE POORLY UNDERSTOOD STRUCTURE AND FUNCTION OF THE ABC TRANSPORTERS Chapter 9: IMPORT OF SOLUTES BY ABC TRANSPORTERS – THE MALTOSE AND OTHER SYSTEMS INTRODUCTION AND GENERAL OVERVIEW THE MALTOSE/MALTODEXTRIN TRANSPORT SYSTEM OF E.

    2001). Subsequent ATP hydrolysis and ADP/Pi release ‘resets’ the transporter for another cycle (Sauna and Ambudkar, 2000). , 1995). However, it is still unclear whether 1 or 2 ATP molecules are hydrolyzed per molecule of substrate transported; determination of this number, together with determination of the exact number of substrate-binding sites and the nature of the conformational changes involved, is crucial to complete elucidation of the transport cycle. CONCLUSIONS ABC transporters are now recognized as one of the most intriguing of all protein families and are of considerable medical significance.

    From the top to the bottom of the figure are represented: a schematic organization of the transporters; the types of proteins encoded by the genes that determine the system; the subfamily of the system and the distribution among living organisms. g. the hemolysin exporter of Gram-negative bacteria) comprise a TolC-like trimeric outer membrane protein (OMP), a probable trimer of a membrane fusion protein (MFP) and a homodimeric complex of an IM-ABC protein.

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